Published June 10, 2025
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LRG1 in cancer: mechanisms, potential therapeutic target, and use in clinical diagnosis.

Creators

  • 1. Children's Hospital of Tlaxcala, Tlaxcala, 90610, Mexico.
  • 2. Faculty of Biotechnology, Popular Autonomous University of the State of Puebla, Puebla City, 72410, Mexico.
  • 3. Department of Physiology, Biophysics, and Neurosciences, Center for Research and Advanced Studies of the IPN, Mexico City, 07360, Mexico.
  • 4. Clinical Chemistry, Faculty of Health Sciences, Autonomous University of Tlaxcala, Tlaxcala, 90750, Mexico. eli.bautista@gmail.com.
  • 5. Facultad de Ciencias de la Salud, Universidad Autónoma de Tlaxcala, Tlaxcala, 90750, Mexico. eli.bautista@gmail.com.
  • 6. Center for Research in Applied Science and Advanced Technology, Morelos Unit, National Polytechnic Institute, Boulevard de la Technology, 1036 Z-1, P 2/2, Atlacholoaya, Morelos, 62790, Mexico.
  • 7. Instituto Politécnico Nacional
  • 8. Direction of Chronic Infections and Cancer, Research Center in Infection Diseases, Instituto Nacional de Salud Pública, Cuernavaca, 62100, Mexico.
  • 9. Environmental Epigenetics and Mental Health Laboratory, Faculty of Chemical Biological Sciences, Autonomous University of Campeche, Campeche, Mexico.
  • 10. Department of Sciences and Engineering, Iberoamerican Puebla University, Puebla, 71820, Mexico.
  • 11. Tlaxcala Center for Behavioral Biology, Autonomous University of Tlaxcala, Tlaxcala, 90070, Mexico.
  • 12. Department of Biology and Cellular Physiology, Institute of Biomedical Research, National Autonomous University of Mexico, Federal Highway Tlaxcala-Puebla km 1.5 s/n, Tlaxcala, 90070, Mexico.
  • 13. National Autonomous University of Mexico
  • 14. Clinical Chemistry, Faculty of Health Sciences, Autonomous University of Tlaxcala, Tlaxcala, 90750, Mexico.

Description

Leucine-rich alpha-2 glycoprotein 1 (LRG1) is an extracellular protein whose elevated expression has been linked to cancers with poor prognosis and low survival rates. Given its significance as a biomarker, this manuscript explores the role of LRG1 in cancer, as several studies have identified it as a promoter of proliferation, angiogenesis, invasion, and metastasis in breast, ovarian, pancreatic, and neuroblastoma cancers. However, contrasting evidence suggests that LRG1 inhibits proliferation in hepatocellular carcinoma cells and suppresses migration and invasion in esophageal squamous cell carcinoma. We also examine its regulation and the associated signaling pathways, including TGF-β and PI3K/AKT/mTOR.
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