Published September 28, 2023
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Effect of Bariatric Surgery on Serum Amyloid A Protein: a Systematic Review and Meta-analysis.

Creators

  • 1. International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.
  • 2. School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
  • 3. Royal College of Surgeons in Ireland Bahrain, Adliya, Kingdom of Bahrain.
  • 4. Diabetes Complications Research Centre, University College Dublin, Dublin, Ireland.
  • 5. University College Dublin
  • 6. Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, Ohio, USA.
  • 7. Cleveland Clinic
  • 8. Heart and Vascular Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates.
  • 9. Department of Basic Medical Sciences, College of Medicine, QU Health, Qatar University, Doha, Qatar.
  • 10. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran. amir_saheb2000@yahoo.com.
  • 11. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. amir_saheb2000@yahoo.com.

Description

Obesity is a chronic inflammatory condition and this meta-analysis evaluated the impact of bariatric surgery on SAA. Studies included all types of bariatric surgery where SAA was measured before and after the surgical procedure. Meta-analysis of 11 clinical studies (n = 394 individuals) confirmed a significant reduction in SAA following bariatric surgery (SMD: - 0.971, 95% CI: - 2.721, 0.779, p < 0.001). Meta-regression did not show any association between the changes in BMI and the absolute difference in SAA levels. No relationship between the changes in SAA and the length of follow-up was found. Bariatric surgery significantly improved SAA. The decrease in SAA was not related to time after surgery or changes in BMI. Bariatric surgery may thus have an independent effect on SAA. © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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