Published March 7, 2025
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Contignasterines, Anti-Inflammatory 2-Aminoimidazole Steroids from the Sponge Neopetrosia cf. rava Collected in the Bismarck Sea.

Creators

  • 1. School of Biological and Chemical Sciences, Ryan Institute, University of Galway, H91TK33 Galway, Ireland.
  • 2. Pharmacology Department, Facultad de Veterinaria, Universidad de Santiago de Compostela, Avenida Carballo Calero s/n, 27002 Lugo, Spain.
  • 3. University of Santiago de Compostela
  • 4. Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Cádiz, Cádiz, 11001, Spain.
  • 5. Instituto de Investigación en Biomoléculas (INBIO), Universidad de Cádiz, Cádiz, 11001, Spain.
  • 6. Biological Sciences Discipline, University of Papua New Guinea, P.O. Box 320, University 134, National Capital District, Port Moresby, 9999, Papua New Guinea.

Description

Sponges of the genus Neopetrosia are known for the production of a large diversity of bioactive metabolites. Contignasterines A (1) and B (2) were isolated as major metabolites of the sponge Neopetrosia cf. rava collected in the Bismarck Sea along with the known and highly bioactive steroid contignasterol (3) possessing a similar oxidized aglycone. Contignasterines are characterized by the presence of a 2-aminoimidazole branched on the side-chains of the oxidized steroid, and 1 also contains an unusual phosphate group at C-7. The anti-inflammatory activities of these compounds were investigated and revealed that all three compounds inhibited the production of pro-inflammatory mediators.
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