The impact of Catechol-O-methyl transferase knockdown on the cell proliferation of hormone-responsive cancers

Tolba, Mai F.; Omar, Hany A.; Hersi, Fatima; Nunes, Ane C. F.; Noreddin, Ayman M.

Published March 21, 2019

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The impact of Catechol-O-methyl transferase knockdown on the cell proliferation of hormone-responsive cancers

1. Ain Shams University
2. Chapman University
3. University of California, Irvine
4. Beni-Suef University
5. University of Sharjah

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Publication Details

Journal article

Journal: Molecular and cellular endocrinology

Publisher: Elsevier BV

ISSN: 18728057

Volume: 488

Pages: 79-88

Persistent Identifiers

MAGID 2925113502

DOI 10.1016/j.mce.2019.03.007 Read more

PMID 30904591 Read more

Funding

Financial Support

Fulbright — Grant: FY2015/2016 Read more

L'Oréal-UNESCO Read more

CNPq/Brazil Science Without Borders Program — Grant: 201385202012-0 Read more

References

Roy . Downregulation of both p21/Cip1 and p27/Kip1 produces a more aggressive pr... Read more

Tenhunen . Soluble and membrane-bound catechol-O-methyltransferase in normal and... Read more

De Santi . Catechol-O-methyltransferase: variation in enzyme activity and inhibi... Read more

Mooberry . Mechanism of action of 2-methoxyestradiol: new developments, Drug Res... Read more

Xiao . The l58Val/Met polymorphism of catechol-O-methyl transferase gene and pro... Read more

Showing first 5 of 54 references.

Scholarly Citations

Cited by other scholarly works

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Showing first 5 of 15 scholarly citations.

MeSH Terms

2-Methoxyestradiolpharmacology Aromatasegenetics Breast Neoplasmspathology Catechol O-Methyltransferasemetabolism Catecholspharmacology Cell Line Cell Proliferation Cell Survivaldrug effects Cyclin-Dependent Kinase Inhibitor p21metabolism Cyclin-Dependent Kinase Inhibitor p27metabolism Docetaxelpharmacology Gene Expression Regulationdrug effects Gene Knockdown Techniques Gene Silencingdrug effects Hormonespharmacology Humans Male Nitrilespharmacology Phosphorylationdrug effects Prostatic Neoplasmspathology RNAmetabolism Receptorsmetabolism Transcription Factor RelAmetabolism

MeSH (Medical Subject Headings) is the NLM controlled vocabulary for indexing biomedical articles. Click any term to view its definition and hierarchy.

Chemical Substances

Catechols

CAS: 0

D002396

Cyclin-Dependent Kinase Inhibitor p21

CAS: 0

D050759

Hormones

CAS: 0

D006728

Nitriles

CAS: 0

D009570

RNA

CAS: 0

D034741

Receptors

CAS: 0

D011960

Transcription Factor RelA

CAS: 0

D051996

Cyclin-Dependent Kinase Inhibitor p27

CAS: 147604-94-2

D050760

Docetaxel

CAS: 15H5577CQD

D000077143

entacapone

CAS: 4975G9NM6T

C071192

2-Methoxyestradiol

CAS: 6I2QW73SR5

D000077584

Aromatase

CAS: EC 1.14.14.1

D001141

Catechol O-Methyltransferase

CAS: EC 2.1.1.6

D002394

13 chemical substances identified from Medical Subject Headings (MeSH).

The impact of Catechol-O-methyl transferase knockdown on the cell proliferation of hormone-responsive cancers

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MeSH Terms

Chemical Substances