Journal of Investigative Dermatology - Antisense long non-coding RNAs are deregulated in skin tissue of patients with systemic sclerosis
Creators
- Messemaker, Tobias1, 2
-
Chadli, Loubna3
- Cai, Guoshuai4
- Goelela, Varshna S.3
- Boonstra, M.1, 2
- Dorjée, Annemarie L.1, 2
- Andersen, S.N.3
- Mikkers, Harald1, 2
- van 't Hof, Peter1, 2
- Mei, Hailiang1, 2
- Distler, Oliver5
- Draisma, Harmen H.M.1, 2
- Johnson, Michael E.4
- Orzechowski, Nicole M.4
- Simms, Robert W.6
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Toes, René E. M.1, 2
- Aarbiou, Jamil3
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Huizinga, Tom W J1, 2
- Whitfield, Michael L.4
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DeGroot, Jeroen3
- de Vries-Bouwstra, Jeska K1, 2
- Kurreeman, Fina A S1, 2
- and 12 more
- 1. Leiden University Medical Center
- 2. Leiden University
- 3. Charles River Laboratories
- 4. Dartmouth College
- 5. University of Zurich
- 6. Boston University
Description
Systemic sclerosis is an autoimmune disease characterized by fibrosis of skin and multiple organs of which the pathogenesis is poorly understood. We studied differentially expressed coding and non-coding genes in relation to systemic sclerosis pathogenesis with a specific focus on antisense non-coding RNAs. Skin biopsy−derived RNAs from 14 early systemic sclerosis patients and six healthy individuals were sequenced with ion-torrent and analyzed using DEseq2. Overall, 4,901 genes with a fold change >1.5 and a false discovery rate
Open Access
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Publication Details
Journal article
Journal:
The Journal of investigative dermatology
Publisher:
Nature Publishing Group
ISSN:
15231747
Volume:
138
Pages:
826-835
Persistent Identifiers
Funding
References
Rubio-Rivas . Mortality and survival in systemic sclerosis: systematic review an...
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Richards . Long non-coding\u00a0RNAs (LncRNA) regulated by transforming growth f...
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Pelechano . Gene regulation by antisense transcription, Nat Rev Genet. 2013; 14 ...
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Harrow . GENCODE: the reference human genome annotation for the ENCODE Project, ...
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Riente . Anti-collagen antibodies in systemic sclerosis and in primary Raynaud\u...
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Scholarly Citations
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Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung