Published December 12, 2023
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Age-specific reference intervals for liver function tests in healthy neonates, infants, and young children in Iran.

Creators

  • 1. Department of Biology, Mashhad Branch, Islamic Azad University, Mashhad, Iran.
  • 2. Islamic Azad University
  • 3. CALIPER Program, Division of Clinical Biochemistry, Pediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • 4. International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.
  • 5. Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
  • 6. Department of Biostatistics, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran.
  • 7. Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada.
  • 8. University of Toronto
  • 9. Department of Clinical Biochemistry, School of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
  • 10. Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, UK.
  • 11. Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Description

The reference intervals (RIs) for liver function tests (LFTs) were determined in Iranian children for the first time. A total of 344 healthy pediatrics aged 3 days to 30 months old were recruited. Serum levels of ALT, AST, ALP, direct bilirubin, and total bilirubin were measured. RIs were determined using CLSI Ep28-A3 guidelines. All analytes demonstrated age-specific differences except AST. ALT and ALP demonstrated significantly elevated levels in infants 0 to <5 months relative to the remainder of the age range. Direct and total bilirubin demonstrated markedly elevated levels in early life with mean of 0.28 mg/dL and 1.64 mg/dL observed for direct and total bilirubin, respectively, decreasing by ~50% in the adjacent partition. These novel data will help improve the clinical interpretation of biochemical test results in young Iranian neonates and children and can be of value to clinical laboratories with similar populations. © 2023 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC.
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