Published 2024
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Recent Update on the Protective Potentials of Resveratrol against Cisplatin-induced Ototoxicity: A Systematic Review.

Creators

  • 1. Department of Clinical Pharmacy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Alkharj, Kingdom of Saudi Arabia.
  • 2. Medical Laboratory Techniques Department, Al-Maarif University College, Al-anbar-Ramadi, Iraq.
  • 3. Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
  • 4. Master's Programme Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
  • 5. Andrology Program, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
  • 6. Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.
  • 7. College of Business Administration, Ajman University, Ajman, United Arab Emirates.
  • 8. Department of Botany, Bahauddin Zakariya University, Multan, Pakistan.
  • 9. Computer Engineering Techniques Department, Faculty of Information Technology, Imam Ja'afar Al-Sadiq University, Baghdad, Iraq.
  • 10. Department of Otorhinolaryngology No.2, Samarkand State Medical Institute, Amir Temur Street 18, Samarkand, Uzbekistan.
  • 11. Department of Scientific Affairs, Tashkent State Dental Institute, Makhtumkuli Street 103, Tashkent, 100047, Uzbekistan.
  • 12. Anesthesia Techniques Department, Al-Mustaqbal University College, Babylon, Iraq.
  • 13. Department of Medical Physics and Radiology, Faculty of Paramedical Sciences, Kashan University of Medical Sciences, Kashan, Iran.
  • 14. Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran.
  • 15. International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.
  • 16. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
  • 17. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Description

Although cancer treatment with cisplatin is effective, dose-dependent adverse effects such as ototoxicity occurs often, which limits its clinical use. The use of resveratrol may alleviate the cisplatin-induced ototoxic effects. This study is aimed to review the potential otoprotective effects of resveratrol against cisplatin-induced ototoxicity. According to the PRISMA guideline, a systematic search was accomplished to identify all relevant scientific papers on "the role of resveratrol against cisplatin-induced ototoxicity" in different electronic databases up to May 2021. Fifty-five articles were screened based on a predefined set of inclusion and exclusion criteria. Eight eligible studies were finally included in the current systematic review. The in-vitro findings revealed that cisplatin administration significantly decreased the HEI-OC1 cell viability compared to the untreated cells; however, resveratrol co-treatment (in a dose-dependent manner) could protect HEI-OC1 cells against cisplatin-induced decrease in cell viability. Furthermore, the in-vivo finding showed a decreased value of DPOAE, and increased values of ABR threshold, ABR-I, ABR-IV, and ABR I-IV interval in cisplatin-treated animals; in contrast, resveratrol co-administration demonstrated an opposite pattern on these parameters. Thus, it can be mentioned that resveratrol co-treatment alleviates cisplatin-induced ototoxicity. Mechanically, resveratrol exerts its otoprotective effects through various mechanisms such as anti-oxidant, anti-apoptosis, and anti-inflammatory. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
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