Published June 26, 2022
2 views Journal article

Oxidant-induced disruption of vascular K+ channel function: implications for diabetic vasculopathy.

Creators

  • 1. Basic Medical Sciences, University of the West Indies, Mona, Kingston, Jamaica.
  • 2. Department of Pharmacy, Faculty of Health Sciences, Arturo Prat University, Iquique, Chile.
  • 3. Department of Physiology, College of Medical Sciences, University of Calabar, Calabar, Nigeria.
  • 4. Department of Pathology, Faculty of Medical Sciences, University of the West Indies, Mona, Kingston, Jamaica.
  • 5. Centre of Metabolism and Inflammation, University College London, London, UK.
  • 6. University College London

Description

Diabetes in humans a chronic metabolic disorder characterised by hyperglycaemia, it is associated with an increased risk of cardiovascular disease, disruptions to metabolism and vascular functions. It is also linked to oxidative stress and its complications. Its role in vascular dysfunctions is generally reported without detailed impact on the molecular mechanisms. Potassium ion channel (K+ channels) are key regulators of vascular tone, and as membrane proteins, are modifiable by oxidant stress associated with diabetes. This review manuscript examined the impact of oxidant stress on vascular K+ channel functions in diabetes, its implication in vascular complications and metabolic and cardiovascular diseases.
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