Trimetazidine protects against doxorubicin-induced chemobrain in rats: Insights into energy imbalance and neuroinflammation.

Eldmnawy, Azza T; Tolba, Mai F; Elghazaly, Hesham; Wahdan, Sara A

Published November 6, 2025

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Trimetazidine protects against doxorubicin-induced chemobrain in rats: Insights into energy imbalance and neuroinflammation.

1. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
2. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt. Electronic address: tolba.mf@pharma.asu.edu.eg.
3. Clinical Oncology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt; Medical Research Center (MASRI), Faculty of Medicine, Ain Shams University, Cairo, Egypt.
4. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt. Electronic address: Sara_wahdan@pharma.asu.edu.eg.

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Publication Details

Journal article

Journal: European journal of pharmacology

Publisher: Elsevier BV

ISSN: 18790712

Volume: 1008

Pages: 178339

Persistent Identifiers

PMID 41205975 Read more

DOI 10.1016/j.ejphar.2025.178339 Read more

Funding

Financial Support

Faculty of Veterinary Medicine, Cairo University Read more

United Nations Educational, Scientific and Cultural Organization Read more

References

Ghosh . Dual-energy precursor and nuclear erythroid-related factor 2 activator t... Read more

Salas-Ramirez . Doxorubicin and cyclophosphamide induce cognitive dysfunction an... Read more

Hall . Emotional behavior in the rat. I. Defecation and urination as measures of... Read more

Pascale . Cardioprotection of trimetazidine and anthracycline-induced acute card... Read more

Liu . Resveratrol improves paclitaxel-induced cognitive impairment in mice by ac... Read more

Showing first 5 of 68 references.

MeSH Terms

Animals Trimetazidinepharmacology Doxorubicinadverse effects Male Rats Rats Neuroprotective Agentspharmacology Chemotherapy-Related Cognitive Impairmentprevention & control Energy Metabolismdrug effects Neuroinflammatory Diseaseschemically induced Antibioticsadverse effects Behaviordrug effects Oxidative Stressdrug effects Braindrug effects Apoptosisdrug effects

MeSH (Medical Subject Headings) is the NLM controlled vocabulary for indexing biomedical articles. Click any term to view its definition and hierarchy.