Published April 11, 2024
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Reversing Metabolic Dysfunction-Associated Steatotic Liver Disease Promotes Healthy Pediatric Cardiovascular Structures: The PROC Study.

Creators

  • 1. Department of Child, Adolescent Health and Maternal Care, School of Public Health, Capital Medical University, Beijing, China.
  • 2. Capital Medical University
  • 3. Department of Microbiology of Infectious Diseases, Yale School of Public Health, and Department of Pediatrics, Yale School of Medicine, Yale University, New Haven, Connecticut, USA.
  • 4. Yale University
  • 5. Department of Hematology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  • 6. UNESCO Chair on Global Health and Education, Peking University, Beijing, China.
  • 7. Peking University
  • 8. Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, China.

Description

We investigated the impact of metabolic dysfunction-associated steatotic liver disease (MASLD) on cardiovascular structure development in children. We followed 1,356 children with the mean age of 6.6 years for 4.5 years in Beijing, China. We assessed the association of MASLD with cardiovascular structure (carotid intima-media thickness and left ventricular mass) outcomes at baseline and follow-up. Over follow-up, 59 children had persistent MASLD, 109 had incident MASLD (progression), and 35 had normalization of liver health. Children with MASLD normalization showed a significantly lower mean development in carotid intima-media thickness (0.161 vs 0.188 mm) and left ventricular mass (4.5 vs 12.4 g) than children with persistent MASLD. The control of MASLD was associated with improved cardiovascular structure development. Copyright © 2024 by The American College of Gastroenterology.
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