Published February 7, 2022
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Fungicidal and anti-aflatoxin activity of four meroterpenoids isolated from Arnebia euchroma root

Creators

  • 1. Department of Horticultural Sciences, Faculty of Agriculture, Shirvan Branch, Islamic Azad University, Shirvan, Iran
  • 2. Islamic Azad University
  • 3. Department of Horticultural Sciences, Faculty of Agriculture, Ferdowsi University of Mashhad, Mashhad, Iran
  • 4. Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
  • 5. Faculty of Medicine, International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran
  • 6. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  • 7. Department of Pharmacognosy, Faculty of Pharmacy, Mashhad University of Medical sciences, Mashhad, Iran
  • 8. Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Description

Meroterpenoids are naturally occurring bioactive compounds derived from terpenoids. Isolation and structure elucidation of four meroterpenoids from Arnebia euchroma root confirmed as arnebinol A–D have been conducted and their antifungal and anti-aflatoxigenic activities against Aspergillus flavus have been investigated. Scanning electron microscopy revealed that after treating A. flavus with arnebinol A–D at ≥200 mg/L, the conidia with phialides appeared wrinkled and compressed, the cell wall was damaged, and mycelial growth was entirely inhibited. Arnebinol D could inhibit A. flavus aflatoxin production and reduce ergosterol levels. The present experiments confirmed the antifungal activity of arnebinol D and provided evidence for the potential use of these natural compounds against fungi.
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