Published February 25, 2025
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Light Exposure, Physical Activity, and Indigeneity Modulate Seasonal Variation in NR1D1 (REV-ERBα) Expression.

Creators

  • 1. Department of Biology, Tyumen Medical University, 625023 Tyumen, Russia.
  • 2. Laboratory for Chronobiology and Chronomedicine, Research Institute of Biomedicine and Biomedical Technologies, Tyumen Medical University, 625023 Tyumen, Russia.
  • 3. Tyumen Cardiology Research Centre, Tomsk National Research Medical Center, Russian Academy of Science, 119991 Tyumen, Russia.
  • 4. Laboratory for Genomics, Proteomics, and Metabolomics, Research Institute of Biomedicine and Biomedical Technologies, Medical University, 625023 Tyumen, Russia.
  • 5. Laboratory of Genetics, Institute of Biology of the Karelian Science Center of the Russian Academy of Sciences, 185910 Petrozavodsk, Russia.
  • 6. Russian Academy of Sciences
  • 7. Institute of Neurosciences and Medicine, 630117 Novosibirsk, Russia.
  • 8. Department Engineering and Architecture, Institute of Building Technology and Energy, Lucerne University of Applied Sciences and Arts, 6048 Horw, Switzerland.
  • 9. Department of Biological & Medical Physics UNESCO, Medical University, 625023 Tyumen, Russia.
  • 10. Department of Molecular Immunology and Biotechnology, Institute of Physiology of the Federal Research Centre Komi Science Centre of the Ural Branch of the Russian Academy of Sciences, 167982 Syktyvkar, Russia.
  • 11. Institute of Biology/Zoology, Martin Luther University Halle-Wittenberg, 06120 Halle, Germany.
  • 12. Department of Integrated Biology and Physiology, University of Minnesota, Minneapolis, MN 55455, USA.
  • 13. University of Minnesota

Description

Nuclear receptor subfamily 1 group D member 1 (NR1D1 or REV-ERBα) is a crucial element of the circadian clock's transcriptional and translational feedback loop. Understanding its expression in humans is critical for elucidating its role in circadian rhythms and metabolic processes, and in finding potential links to various pathologies. In a longitudinal survey, we examined REV-ERBα expression at 08:00 using a real-time polymerase chain reaction (qRT-PCR) in blood mononuclear cells from Arctic native and non-native residents during equinoxes and solstices. REV-ERBα expression exhibited a pronounced seasonality, peaking at the summer solstice, and reaching a nadir at the winter solstice in both natives and non-natives, with a relatively higher summer peak in natives. After adjusting for age, sex, and body mass index, the amount and timing of light exposure, the amount of physical activity, and indigeneity emerged as significant predictors of REV-ERBα expression.
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