Published November 3, 2025
0 views Journal article Open Access Open Access

Anti-IL-17 and Anti-IL-23 Therapies Modulate Serum Biomarkers of Intestinal Dysbiosis and Oxidative Stress Linked to Cardiovascular Risk in Patients with Psoriasis.

Creators

  • 1. Dipartimento di Psicologia e Scienze della Salute, Università Telematica Pegaso, Via Porzio, Centro Direzionale Isola F2, 80143 Naples, Italy.
  • 2. Laboratory of Experimental Immunology, Istituto Dermopatico dell'Immacolata, IDI-IRCCS, 00167 Rome, Italy.
  • 3. Scientific Institute for Research, Hospitalization and Healthcare
  • 4. Department of Dermatology, Istituto Dermopatico dell'Immacolata, IDI-IRCCS, 00167 Rome, Italy.
  • 5. Unità di Endocrinologia, Diabetologia ed Andrologia, Dipartimento di Medicina Clinica e Chirurgia, University of Naples Federico II, 80131 Naples, Italy.
  • 6. University of Naples Federico II
  • 7. Centro Italiano per la Cura e il Benessere del Paziente con Obesità (C.I.B.O), University of Naples Federico II, 80131 Naples, Italy.
  • 8. Cattedra Unesco "Educazione Alla Salute E Allo Sviluppo Sostenibile", University of Naples Federico II, 80131 Naples, Italy.
  • 9. Department of Pharmacy, University of Naples Federico II, 80131 Naples, Italy.

Description

Psoriasis is a chronic inflammatory skin disease whose pathogenesis involves not only cutaneous inflammation but also intestinal dysbiosis and oxidative stress (OxS). Monoclonal antibodies targeting interleukin (IL)-17 and IL-23 have demonstrated significant immunomodulatory effects; however, their impact on systemic parameters requires further investigation. We conducted a study on 33 patients with plaque psoriasis treated with anti-IL-17 or anti-IL-23 monoclonal antibodies. Dermatological parameters (Psoriasis Area and Severity Index (PASI) and Dermatology Life Quality Index (DLQI)), biomarkers of intestinal dysbiosis (trimethylamine-N-oxide (TMAO)) and OxS (reactive oxygen metabolites (d-ROMs) and oxidized LDL (oxLDL)) were evaluated. Anthropometric, metabolic, and adipose-derived hormonal parameters (adipokines) were also monitored. After 16 weeks of therapy, significant improvements were observed in PASI and DLQI scores (p p = 0.02), as were d-ROMs and oxLDL (p < 0.001). No significant changes were found in weight, body mass index, lipid profile, or adipokine levels (visfatin, leptin and adiponectin). Our data indicate that monoclonal antibody therapy not only improves psoriasis severity but also exerts beneficial effects on systemic biomarkers of dysbiosis and OxS, independent of metabolic or hormonal changes. These findings suggest a systemic mechanism of action, supporting a multifactorial therapeutic effect with potential implications for the prevention of cardiovascular risk.
Enabled by The Lens

Open Access

Licence Attribution (CC BY)
Publisher Website Access full text