Editorial: Fighting microbial biofilms: novel therapeutics and antibiofilm strategies.

Biofilm-associated infections.Biofilms present researchers with a range of challenges and opportunities, particularly due to their complex architecture, persistence and resistance to conventional treatments, and pivotal role in chronic infections (Almatroudi, 2025;Coenye et al., 2024;Paraje, 2018). In recent years, numerous antibiofilm compounds and alternative strategies have been identified, aimed at preventing biofilm formation or promoting biofilm dispersal to eradicate mature communities (Zhao et al., 2023). The articles compiled in this Research Topic address these pressing issues by focusing on the development of novel therapeutics, innovative techniques, and safe, effective alternative approaches, reflecting the rapidly evolving landscape of this critical field. The collection also underscores the importance of interdisciplinary collaboration. By bridging diverse scientific disciplines-including microbiology, nanotechnology, pharmacology, and clinical medicine-these contributions offer a comprehensive and contemporary perspective on biofilm research, while proposing novel therapeutic avenues to tackle the global challenge of biofilm-associated infections (Paraje, 2023;Da Silva et al., 2024). Altogether, this Research Topic compiles state-of-the-art investigations into biofilm formation, maturation, and disruption, providing a forwardlooking overview of both current challenges and future opportunities in the field. In conclusion, the twelve articles published in the Research Topic "Fighting Microbial Biofilms: Novel Therapeutics and Antibiofilm Strategies" underscore the dynamic and rapidly advancing landscape of biofilm research. Collectively, these contributions shed light on significant progress in our understanding of how biofilms can be effectively targeted and disrupted through innovative antibiofilm agents and therapeutic strategies that act upon critical stages of biofilm development.The Topic Editors extend their sincere gratitude to all contributing authors for their high-quality work and to the reviewers and editors whose thoughtful feedback and scientific rigor greatly enhanced the content of this collection.Their commitment and expertise were instrumental in bringing this Research Topic to fruition. We are equally thankful to our readers for their engagement and enthusiasm for this important and evolving field. It is our hope that this Special Issue will inspire interdisciplinary collaboration and innovation in the development of effective, targeted, and sustainable strategies to combat biofilms and their impact on human, animal, and environmental health, in alignment with the One Health approach.